Pyrrolizidine Alkaloid Content of Houndstongue (Cynoglossum officinale L.)

Nco coramandaline, a pyrrolizidine alkaloid from Cynoglossum furcatum

The basic properties of many pyrrolizidine alkaloids are well known l.5, A lthough they have been isolated from representatives of about 13 plant fami lies, they occur most abundantly in the large genera sen~cio (Asteraceae), Crola/aria (Papilionaceae) and in many members of Boraginaceae including Heliotropium and CynoglossUlI1. More recently they have been detected in LepidopheraJ,4 Over 75 sp...

Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses.

Houndstongue (Cynoglossum officinale), a noxious weed that contains pyrrolizidine alkaloids (PAs), infests pastures and fields in the western United States and Europe. The purpose of this study was to develop techniques to better diagnose PA poisoning and describe the progression of gross and microscopic lesions caused by houndstongue intoxication. Six horses were gavaged daily with a suspensio...

Pyrrolizidine Alkaloid– Containing Toxic Plants (<i>Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, </i> and <i>Echium</i> spp.)

Selective seed abortion increases offspring survival in Cynoglossum officinale (Boraginaceae).

Selective embryo abortion is one of the evolutionary explanations for the surplus of ovules found in many plant species. To manipulate the level of embryo abortion, we removed ovules and applied nutrients to plants of Cynoglossum officinale (Boraginaceae) after they started to flower. From these two treatments and a control series, seeds were collected, germinated, and transplanted in the field...

Pyrrolizidine alkaloid clivorine-induced oxidative stress injury in human normal liver L-02 cells.

Clivorine is an otonecine-type pyrrolizidine alkaloid isolated from the traditional Chinese medicine Ligularia hodgsonii Hook. Pyrrolizidine alkaloids (PAs) are well-known hepatotoxins widely distributed around the world. The present study sought to evaluate clivorineinduced oxidative injury in human normal liver L-02 cells. After cells were treated with various concentrations of clivorine for ...